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![4-Sulfocalix[6]arene hydrate](userfiles/product/PC-49331.gif)
Chemical Structure : 4-Sulfocalix[6]arene hydrate
Catalog No.: PC-49331Not For Human Use, Lab Use Only.
4-Sulfonic calix[6]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release.
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4-Sulfonic calix[6]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release.
4-Sulfonic calix[6]arene shows IC50 of 2.2 and 3.0 uM for poly dA:dT-induced cell death and IL-1β release respectively.
4-Sulfonic calix[6]arene is effective at blocking dsDNA-induced inflammasome activation in LPS-primed human blood monocyte-derived macrophages (hMDMs).
4-Sulfonic calix[6]arene caused a dose-dependent inhibition in poly dA:dT-induced IFN-β release from murine BMDMs with IC50 of 10.72 uM, also reduced the phosphorylation of TBK1 and IRF-3 to a similar extent as the STING inhibitor H151.
| M.Wt | 1117.1 | |
| Formula | C42H36O24S6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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